What You Need To Know – Wednesday, February 25, 2026 PM Edition

Rachel Scott reports on Defense Secretary Pete Hegseth sending a warning to AI maker “Anthropic” – and what it could mean for national security and the future of warfare; Jay O’Brien in Washington with the political firestorm over the Jeffrey Epstein files intensifying – with new questions about what’s been released and what hasn’t; new details on the moving crew that helped save a kidnapped girl; a massive sinkhole swallows part of a street in Nebraska; and the air taxi service from Uber set to take flight.

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It’s been four years since Russia launched a full-scale invasion of Ukraine. Now, peace talks appear to be at an impasse and the death toll keeps rising. NPR’s correspondent in Kyiv takes us inside the war and where things stand now.

The cost of gene therapy can be a barrier for many people who need it. But now, a startup has created a new way to deliver the expensive medicines, called CRISPR, to patients around the world.

Also this week, we talk to Abigail Spanberger, who will give the Democratic response to President Trump’s State of the Union address tonight. Plus, a new NPR investigation found that the public database of Epstein files is missing some related to abuse allegations against Trump.

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